NEXTPROT: A KNOWLEDGE PLATFORM FOR HUMAN PROTEINS.

Pascale Gaudet, Swiss Institute of Bioinformatics, Geneva, Switzerland

Pascale Gaudet, Jonas Cicenas, Isabelle Cusin, Valérie Hinard, Monique Zahn, Lydie Lane, and Amos Bairoch

neXtProt (http://www.nextprot.org/) is a human protein-centric knowledge platform. Developed by it aims to help researchers answer questions relevant to human proteins. To achieve this goal, neXtProt is built on a corpus containing both curated knowledge originating from the UniProtKB/Swiss-Prot knowledgebase, and carefully selected and filtered high-throughput data pertinent to human proteins. The CALIPHO group also develops a tool, the BioEditor, to capture annotations directly from the literature. With this tool we have annotated 300 protein kinases with precise descriptions of their molecular and biological functions, as well as their roles in diseases or as disease diagnosis tools. This presentation will give an overview of the different activities of the CALIPHO group in bioinformatics.