Proteome of radiotherapy resistance: kinases as drug targets.

Algirdas Kaupinis, Proteomics Centre, Vilnius, Lithuania

Jonas Cicenas, Algirdas Kaupinis, Mindaugas Valius

Radiation therapy plays a major role in the management of patients with different cancers, but failure remains a significant problem. Different patients with tumors that are the same size, grade and stage can respond differently to radiotherapy. Radiotherapy resistance could be the relative resistance of individual cells, tissues, organs, or entire organisms to the biologic effects of radiation therapy. In this study we assessed the difference between protein expression in wild-type cells and radioresistant derivatives.