MAPK1 HUMAN

Name: Mitogen-activated protein kinase 1 - human

Alternative names: Erk2, p42-MAPK, MAPK2

Taxonomy: [Homo sapiens] Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi; Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo.

Protein Size: 360 aa

mRNA Size: 5916 bp

MW: 41390 Da

pI: 6.5

Activator MKKs: MAP2K1 (MEK1); MAP2K2 (MEK2)

Activation site: TEY (pThr-185 and pTyr-187)

Protein sequence [FASTA]:

>mkr|HOS000001|MK1_HUMAN|Mitogen-activated protein kinase 1 
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS

Cross references

RefSeq: Protein: NP_002736.3. Nucleotide sequence: NM_002745.4.
RefSeq: Protein: NP_620407.1. Nucleotide sequence: NM_138957.2.
NCBI Gene: 5594 [ MAPK1 mitogen-activated protein kinase 1 ]
UniProtKB: P28482 [ MAPK1 ]
NextProt: NX_P28482 [ Mitogen-activated protein kinase 1 ]
HPRD: 01496 [ ERK2 ]
RCSB PDB: 1PME
RCSB PDB: 1TVO
RCSB PDB: 1WZY
RCSB PDB: 2E14
RCSB PDB: 2OJG
RCSB PDB: 2OJI
RCSB PDB: 2OJJ
RCSB PDB: 3I5Z
RCSB PDB: 3I60