MAPK11 HUMAN

Name: Mitogen-activated protein kinase 11 - human

Alternative names: P38beta, SAPK2b, p38-2, Prkm11

Taxonomy: [Homo sapiens] Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi; Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo.

Protein Size: 364 aa

mRNA Size: 2420 bp

MW: 41357 Da

pI: 5.56

Activator MKKs: MAP2K3 (MKK3); MAP2K5 (MKK5); MAP2K6 (MKK6)

Activation site: TGY (pThr-180 and pTyr-182)

Protein sequence [FASTA]:

>mkr|HOS000011|MK11_HUMAN|Mitogen-activated protein kinase 11 
MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ
SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ
ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG
TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA
EALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSL
EIEQ

Cross references

RefSeq: Protein: NP_002742.3. Nucleotide sequence: NM_002751.5.
NCBI Gene: 5600 [ MAPK11 mitogen-activated protein kinase 11 ]
UniProtKB: Q15759 [ MAPK11 ]
NextProt: NX_Q15759 [ Mitogen-activated protein kinase 11 ]
HPRD: 04208 [ MAPK11 ]
RCSB PDB: 3GP0 [ MAPK11 ]
RCSB PDB: 3GC9 [ p38beta ]
RCSB PDB: 3GC8 [ p38beta ]