MAPK12 HUMAN

Name: Mitogen-activated protein kinase 12 - human

Alternative names: P38gamma, SAPK3, Erk6

Taxonomy: [Homo sapiens] Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi; Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo.

Protein Size: 367 aa

mRNA Size: 1778 bp

MW: 41940 Da

pI: 5.98

Activator MKKs: MAP2K3 (MKK3); MAP2K5 (MKK5); MAP2K6 (MKK6)

Activation site: TGY (pThr-183 and pTyr-185)

Protein sequence [FASTA]:

>mkr|HOS000012|MK12_HUMAN|Mitogen-activated protein kinase 12 
MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM
KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS
EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMK
VTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV
TAGEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTLDEWKRVTYKEVLSFKPPRQLGAR
VSKETPL

Cross references

RefSeq: Protein: NP_002960.2. Nucleotide sequence: NM_002969.3.
NCBI Gene: 6300 [ MAPK12 mitogen-activated protein kinase 12]
UniProtKB: P53778 [ MAPK12 ]
NextProt: NX_P53778 [ Mitogen-activated protein kinase 12]
HPRD: 03868 [ MAPK12 ]
RCSB PDB: 1CM8 [ P38gamma ]