MAPK14 HUMAN

Name: Mitogen-activated protein kinase 14 - human

Alternative names: P38alpha, SAPK2a, CSBP, CSBP1, CSBP2, CSPB1, MXI2

Taxonomy: [Homo sapiens] Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi; Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo.

Protein Size: 360 aa

mRNA Size: 2420 bp

MW: 41293 Da

pI: 5.48

Activator MKKs: MAP2K3 (MKK3); MAP2K5 (MKK5); MAP2K6 (MKK6)

Activation site: TGY (pThr-180 and pTyr-182)

Protein sequence [FASTA]:

>mkr|HOS000014|MK14_HUMAN|Mitogen-activated protein kinase 14 
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES

Cross references

RefSeq: Protein: NP_620581.1. Nucleotide sequence: NM_139012.2.
RefSeq: Protein: NP_001306.1. Nucleotide sequence: NM_001315.2.
RefSeq: Protein: NP_620583.1. Nucleotide sequence: NM_139014.2.
RefSeq: Protein: NP_620582.1. Nucleotide sequence: NM_139013.2.
NCBI Gene: 1432 [ MAPK14 mitogen-activated protein kinase 14 ]
UniProtKB: Q16539 [ MAPK14 ]
NextProt: NX_Q16539 [ Mitogen-activated protein kinase 14 ]
HPRD: 02619 [ MAPK14 ]
RCSB PDB: 3HVC [ p38alpha ]
RCSB PDB: 1R39 [ p38alpha ]