MAPK8 HUMAN

Name: Mitogen-activated protein kinase 8 - human

Alternative names: JNK1,JNK-46, SAPK1, Prkm8

Taxonomy: [Homo sapiens] Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi; Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea; Hominidae; Homininae; Homo.

Protein Size: 427 aa

mRNA Size: 1412 bp

MW: 48296 Da

pI: 6.43

Activator MKKs: MAP2K4 (MKK4};MAP2K5 (MKK5); MAP2K7 (MKK7)

Activation site: TPY (pThr-183 and pTyr-185)

Protein sequence [FASTA]:

>mkr|HOS000008|MK8_HUMAN|Mitogen-activated protein kinase 8 
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA
GPLGCCR

Cross references

RefSeq: Protein: NP_002741.1. Nucleotide sequence: NM_002750.2.
RefSeq: Protein: NP_620637.1. Nucleotide sequence: NM_139049.1.
RefSeq: Protein: NP_620635.1. Nucleotide sequence: NM_139047.1.
RefSeq: Protein: NP_620634.1. Nucleotide sequence: NM_139046.1.
NCBI Gene: 5599 [ MAPK8 mitogen-activated protein kinase 8 ]
UniProtKB: P45983 [ MAPK8 ]
NextProt: NX_P45983 [ Mitogen-activated protein kinase 8 ]
HPRD: 03100 [ MAPK8 ]
RCSB PDB: 3O17 [ JNK1 ]
RCSB PDB: 3PZE [ JNK1 ]